李峰伟

副研究员

 

详细介绍

李峰伟，副研究员，研究方向：（1）基于AI+生物制造挖掘海水中（Li, U, Cs等）能源金属离子新策略研究（2）线粒体死亡相关靶标特异性大环肽抑制剂的筛选及大环肽透膜机制研究

简历（工作学习）

2007.09-2011.07  枣庄学院 本科

2011.09-2016.12  厦门大学 博士

2017.03-2019.04  中国科学院青岛生物能源与过程研究所 博士后

2019.05-2020.11  山东大学 专聘副研究员

2020.11-2024.01  特别资助类 博士后

2024.03-至今       中国科学院青岛生物能源与过程研究所 副研究员

承担科研项目情况

1、国家自然科学基金委员会, 青年科学基金项目, 31800664, 铁氧还蛋白调控P450催化活性的结构机制研究。

2、中国博士后科学基金, 面上项目, 2021M691949, 基于PROTAC技术研究Bcl-XL特异性抑制剂的结构及功能机制。

3、中国博士后科学基金, 面上项目, 2017M622293, 基于ZouA的基因倍增技术提高弗氏链霉菌泰勒菌素产量。

4、山东省博士后创新项目2项。

5、青岛市博士后应用项目2项。

代表论著

1. Fengwei Li^#*, Chao Liu^#, Ziyan Liu^#, Junjie Liu, Xiangda Peng, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen, Dian Xiong, Xiantong Diao, Jingjing Zhuang, Chuanliu Wu*, Dalei Wu*. Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy. Nature communications. 2024 Feb 17;15(1):1476 (第一作者兼共同通讯作者)

2.  Fengwei Li^#*, Mengmeng Zhang^#, Chao Liu^#， Jie Cheng, Yawen Yang, Xiangda Peng, Zhifeng Li, Wenfeng Cai, Haipeng Yu, Junjie Wu, Yuyu Guo, Hongkun Geng, Yun Fa, Youming Zhang, Dalei Wu*, Yizhen Yin*. De novo Discovery of a Molecular Glue-like Macrocyclic Peptide that Induces MCL1 Homodimerization. PNAS. 2025, accepted. (第一作者兼共同通讯作者)

3. Jihe Zhao, Lei Zhao, Quan Cao, Guangying Fu, Fengwe Li*, Huizhou Liu*, Yun Fa*. Skeleton design engineering of covalent organic frameworks to enable in situ incorporation of coordination sites for improved extraction of uranyl ions. chemical engineering journal, 2024，(共同通讯作者, IF:13.3)

4. Xiaohui Liu ^#, Fengwei Li ^#, Tianjian Sun, Jiawei Guo, Xingwang Zhang, Xianliang Zheng, Lei Du, Wei Zhang, Li Ma, Shengying Li. Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution, Communications Biology. 2022, 5(1):791. (IF:6.548, 中科院 1 区)

5. Fengwei Li, Chun Song, Youming Zhang, Dalei Wu. Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for small-molecule drugs. Acta Biochimica et Biophysica Sinica. 2021, 54(1),（IF: 3.5，中科院 2 区）

6. Fengwei Li*, Li Ma, Xingwang Zhang, Jingfei Chen, Feifei Qi, YinyueHuang, Zhepeng Qu, Lishan Yao, Wei Zhang, Eung-Soo Kim*, Shengying Li*, Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana, Synthetic and Systems Biotechnology. 2020, 5, 236-243. (独立一作兼共同通讯作者, IF:4.78 中科院 2区 )

7. Weijia Wang^#, Yuan Wang^#, Fengwei Li^#, Bo Zhou, Xueli Bian, Qixu Cai, YongZhen Xing, Jianping He, Hongkui Zhang, Peiqiang Huang, Tianwei Lin*, Qiao Wu*, Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity, Chemistry & Biology. 2015, 22(8): 1040-1051. (IF:9.039 中科院 1 区)

8.  Li Li^#, Yuan Liu^#, Hangzi Chen^#, Fengwei Li^#, Jianfeng Wu, Hongkui Zhang, Jianping He, Yongzhen Xing, Yan Chen, Weijai Wang, Xuyang Tian, Anzhong Li , Qian Zhang, Peiqiang Huang, Jiahuai Han, Tianwei Lin*, Qiao Wu*. Impeding the Interaction between Nur77 and p38 Reduces LPS-Induced Inflammation, Nature Chemical Biology, 2015, 11(5): 339-346. (共同第一作者，IF:14.8 中科院1 区)

9. Weijia Wang^#, Yuan Wang^#, Hangzi Chen^#, Yongzhen Xing^#, Fengwei Li^#, Qian Zhang, Bo Zhou, Hongkui Zhang, Jia Zhang, Xueli Bian, Li Li, Yuan Liu, Bixing Zhao, Yan Chen, Rong Wu, Anzhong Li, Luming Yao, Ping Chen, Yi Zhang, Xuyang Tian, Friedrich Beermann, Mian Wu, Jiahuai Han, Peiqiang Huang, Tianwei Lin*, Qiao Wu*, Orphan Nuclear Receptor TR3 Acts in Autophagic Cell Death Via Mitochondrial Signaling Pathway, Nature Chemical Biology. 2014, 10(2), 133-140. (共同第一作者，IF:14.8 中科院1 区)

联系方式

15394457228

lifw@qibebt.ac.cn